Increased Glucocorticoid Receptor β Alters Steroid Response in Glucocorticoid-insensitive Asthma
نویسندگان
چکیده
منابع مشابه
Is there a role for glucocorticoid receptor β in asthma?
Glucocorticoids (GCs) are routinely used as anti-inflammatory drugs in the treatment of asthma. They act through binding to glucocorticoid receptor α (GRα), which represses numerous genes encoding pro-inflammatory mediators. A hormone binding deficient GR isoform named GRβ has been isolated in humans. When overexpressed by transfection, GRβ may function as a dominant negative modulator of GRα. ...
متن کاملAssociation of Glucocorticoid Insensitivity with Increased Expression of Glucocorticoid Receptor β
In many chronic inflammatory disorders, glucocorticoid (GC) insensitivity is a challenging clinical problem associated with life-threatening disease progression. The molecular basis of GC insensitivity, however, is unknown. Alternative splicing of the GC receptor (R) pre-messenger RNA generates a second GCR, termed GCR-beta, which does not bind GCs but antagonizes the transactivating activity o...
متن کاملNucleocytoplasmic trafficking of steroid-free glucocorticoid receptor.
Glucocorticoid receptor (GR) recycles between an inactive form complexed with heat shock proteins (hsps) and localized to the cytoplasm and a free liganded form that regulates specific gene transcription in the nucleus. We report here that, contrary to previous assumptions, association of GR into hsp-containing complexes is not sufficient to prevent the shuttling or trafficking of the GR across...
متن کاملGlucocorticoid receptor-binding characteristics in severe asthma.
The cellular mechanisms associated with severe asthma are still poorly understood. This study investigated the association between glucocorticoid-receptor (GR) alterations and continuous oral glucocorticoid therapy requirement in severe asthma. GR-binding affinity (Kd) and receptor number (n) in peripheral blood monocytes (PBM) obtained from 10 normal subjects, 10 untreated, intermittent asthma...
متن کاملExpression of glucocorticoid receptors a and b in steroid sensitive and steroid insensitive interstitial lung diseases
Background: Sensitivity to glucocorticoids may be related to the concentration of glucocorticoid receptors a (GRa) and b (GRb). A study was undertaken to assess GRa and GRb expression in steroid insensitive interstitial lung disease (idiopathic pulmonary fibrosis (IPF)) and steroid sensitive interstitial lung diseases (sarcoidosis and cryptogenic organising pneumonia (COP)). Methods: Lung tissu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Respiratory and Critical Care Medicine
سال: 2006
ISSN: 1073-449X,1535-4970
DOI: 10.1164/rccm.200507-1046oc